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在新诊断多发性髓瘤的老年患者中 Sarcopenia
Paula Sobrini-Morillo1, Celia Corral-Tuesta2, Carmen Sánchez-Castellano2
1Servicio de Geriatría, Hospital Universitario Puerta de Hierro de Majadahonda, Madrid, Spain, paula.sobrini@salud.madrid.org.
Gerontology
|November 17, 2025
概括
标志着肌肉质量和功能的低,影响老年多发性骨髓瘤 (MM) 患者的生存率. 这项研究突出了sarcopenia的重点.
科学领域:
- 老年医学 老年医学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 萨科佩尼亚是一种与年龄相关的疾病,肌肉质量和功能较低,与不良结果有关.
- 多发性骨髓瘤 (MM) 中的肉类的患病率和预后意义尚不清楚,之前的研究往往忽视了肌肉功能.
- 欧洲老年人肉症工作组2 (EWGSOP2) 标准为肉症提供了一个标准化的定义.
研究的目的:
- 用EWGSOP2的定义来确定老年MM患者的肉类的患病率.
- 调查萨科佩尼亚与老年综合征的关联以及MM患者的生存结果.
- 评估MM患者肌肉质量和功能的预后值.
主要方法:
- 这是一项前性研究,涉及65岁或以上的新诊断MM的患者.
- 综合老年评估 (CGA),包括手握力和步行速度.
- 在L3脊椎水平上,对肌肉质量,皮下和内脏脂肪组织的正子发射断层扫描-计算机断层扫描 (PET-CT) 的分析.
主要成果:
- 萨科佩尼亚是普遍存在的,61.5%的人表现出可能的萨科佩尼亚 (肌肉强度低) 和12.5%的确诊的萨科佩尼亚 (肌肉强度和质量低).
- 与非sarcopenic患者相比,sarcopenic患者的整体存活期 (OS) 显著较短 (43.1 与 18.0 个月,p = 0.001).
- 低肌肉质量独立地与较差的生存结果 (HR: 46.8) 和疾病进展风险增加 (HR: 25.34) 相关.
结论:
- 这项研究是第一个使用肌肉数量和功能来评估老年MM患者的肉症.
- 麻症与MM患者的整体存活率降低有关.
- 低骨肌肉质量指数是较短无进展生存的重要预测指标,需要在更大的队列中进一步调查.
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