根据性状,使用捐赠精子是否会增加孕前的风险?
Begoña Prieto1,2,3,4, Natalia Sanz3, María Díaz-Nuñez1
1Human Reproduction Unit, Cruces University Hospital, Baracaldo, Spain.
JBRA assisted reproduction
|November 17, 2025
概括
在接受捐赠者授精的妇女中,不论性取向或先前的精子暴露,孕前的风险都相似. 用捐赠精子进行人工授精是所有女性的一种安全技术.
科学领域:
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
- 产科 产科 产科 产科 产科
背景情况:
- 供体授精与妊娠前风险增加有关,可能是由于对精液的免疫耐受性发生变化.
- 以前的精子暴露可能会影响孕前的发生率,但这还没有在不同患者群体中进行研究.
研究的目的:
- 与异性恋夫妇相比,调查单身妇女,女同性恋妇女和接受捐赠者授精的跨性别伴侣 (SLTG) 妇女的孕前率.
- 为了确定性取向或先前的精液暴露是否会影响子前风险.
主要方法:
- 一项通过捐赠精子授精实现的24周以下439次怀孕的比较研究.
- 分析了两个组:异性恋夫妇和SLTG患者.
- 在不同组之间比较了孕前率和围产期结局.
主要成果:
- 在SLTG组 (6.03%) 和异性恋组 (5.83%) 之间没有观察到妊娠前发病率的显著差异.
- SLTG组的平均年龄和BMI略高,但经过调整后的分析显示没有增加孕前风险.
- 受影响妇女的更低的妊娠年龄和新生儿体重证实了孕前症的严重程度.
结论:
- 性取向和先前的精子暴露似乎不会增加在供体授精后产前的风险,尤其是在对混因素进行调整后.
- 捐赠者授精是一种安全有效的生殖技术,适用于单身女性,女同性恋女性和跨性别伴侣的女性,与异性恋夫妇的使用相比.
相关概念视频
01:41Spermatogenesis
121.4K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.4K
01:23Infertility in Males
516
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
516