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在患有唐氏综合征的个体中,对耳朵,鼻子和2D:4D数字比的形态分析

Zeynep Sena Coşar¹, Aynur Emine Çiçekcibaşi, Gülay Açar

¹Department of Anatomy, Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Turkey.

The Journal of craniofacial surgery

|November 17, 2025

概括

患有唐氏综合征 (DS) 的儿童表现出与年龄相关的面发育. 2D:4D数字比例因性别而异,为DS的临床应用提供了见解.

科学领域:

遗传学和人类生物学
人类测量和生物力学
临床形学临床形学临床形学

背景情况:

唐氏综合症 (DS) 是一种常见的染色体疾病,具有特征性的面特征.
了解DS的面发育对于临床管理至关重要.
在DS的表型变异性需要详细的形态学分析.

研究的目的:

为了评估耳朵,鼻子和2D:4D数字比率形态学在儿童DS.
为了研究这些参数,年龄,性别和横向化之间的关系.
为改善唐氏综合征的临床应用提供数据.

主要方法:

研究包括40名患有DS的儿童 (2-13岁).
人类测量和摄影测量方法评估了鼻子和耳朵的尺寸.
计算了第二到第四位数的比率 (2D:4D).

主要成果:

2D:4D数字比率显示出基于性别的显著差异 (P <0.05).
在测量参数中没有观察到显著的横向差异.
所有面和手指比率参数都与年龄呈正相关.

结论:

在DS中,头面部特征表现出年龄依赖的发展.
2D:4D比率的性别特异性差异存在于患有DS的儿童中.
这些发现支持早期诊断,遗传咨询和定制辅助设备设计.

关键词:

2D:4D比率是什么意思唐氏综合征是什么意思耳朵耳朵耳朵耳朵面部形态测量面部形态测量鼻子鼻子鼻子鼻子

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