通过辅助生殖技术出生的儿童患ADHD的风险:系统性审查和元分析
Puneet Rana Arora1, Ritu Sirohi1, Priyadarshini Puri2
1Department of Reproductive health & Fertility, CIFAR-Centre for Infertility & Assisted Reproduction, Gurugram 122009, Haryana, India.
Journal of tropical pediatrics
|November 17, 2025
概括
像试管婴儿这样的辅助生殖技术 (ART) 稍微增加了儿童的ADHD风险,但整体风险仍然很小. 这一发现为家长和临床医生提供了关于发展结果的保证.
科学领域:
- 生殖医学 生殖医学
- 发育儿科 发育儿科
- 流行病学 流行病学
背景情况:
- 辅助生殖技术 (ART) 在全球越来越多地使用.
- 潜在的神经发育影响,如注意力缺陷多动障碍 (ADHD),需要彻底调查.
研究的目的:
- 系统地评估ART与儿童ADHD风险之间的关联.
- 利用元分析综合从队列和病例对照研究中获得的证据.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Scopus) 进行全面的文献搜索.
- 包括队列和病例控制研究;使用95%置信区间 (CI) 的危险比率 (HR) 计算的聚合效应大小.
- 亚组分析 (性别,怀孕次数,妊娠年龄) 和证据确定性评估 (GRADE).
主要成果:
- 包括体外受精 (IVF) /细胞内质精子注射 (ICSI) 在内的ART受孕显示,ADHD风险略有增加 (HR1.07,95%CI:1.04,1.10),确定性中等.
- 排卵诱导/子宫内授精也表明中等确定性增加的风险 (HR 1.13,95% CI:1.04,1.23).
- 两性,单独怀孕和满期分娩都观察到增加的风险;多胎妊娠或早产的风险并不显著.
结论:
- 通过人工智能疗法受孕的儿童有较小,但在统计学上显著的ADHD风险增加,得到了中等确定性证据的支持.
- 风险的严重程度对家庭和医疗保健提供者来说令人放心.
- 建议包括长期监测,发育查和对ART受孕儿童的家长咨询.
关键词:
在体外受精 (IVF)辅助生殖技术 (ART) 是一种助孕技术.注意力缺陷多动性障碍注意力缺陷多动性障碍细胞体内精子注射 (ICSI) 是一种精子注射.宫内授精 (IUI) 是一种方法.进行元分析.更多相关视频
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