肝脏组织工程的空间模式策略:生物制造技术和应用
Haram Nah1, Ashlin R Michell1, Kerry M Rogy1
1Department of Biomedical Engineering, University of Illinois Chicago, Chicago, USA.
Advanced drug delivery reviews
|November 17, 2025
概括
使用生物制造策略的工程肝脏组织可以复制本地肝脏结构和功能. 这些先进的模型对于药物开发,疾病建模和再生医学至关重要,更接近临床转化.
科学领域:
- 生物技术是生物技术.
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- 肝脏复杂的细胞组织对其众多功能至关重要.
- 复制这种结构是药物开发和再生医学的关键.
- 生物制造提供了创造工程肝脏组织的方法.
研究的目的:
- 审查工程肝脏组织中空间控制的生物制造策略.
- 评估捕捉生理特征的方法,如区分和血管网络.
- 讨论药物查,疾病建模和治疗应用方面的进展.
主要方法:
- 对自组装聚合物,软光刻,电脚架,3D生物打印和微流体技术的审查.
- 基于其模仿本地肝脏架构的能力对方法的评估.
- 突出结合多种生物制造模式的混合方法.
主要成果:
- 各种生物制造技术在重建肝脏组织复杂性方面表现有前途.
- 工程肝脏模型正在推进药物代谢和毒性查.
- 这些模型有助于疾病建模和探索治疗应用.
结论:
- 工程肝脏模型对于 in vitro 和 in vivo 研究的桥梁是必不可少的.
- 需要解决可扩展性,可复制性和标准化方面的挑战.
- 未来的方向包括体积生物打印,机器学习和监管资格.
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