早期阿片类药物处方与远距离半径骨折后新持续使用之间的关联:回顾性队列研究
Eve R Glenn1, Grace Q Chen1, Indeevar R Beeram1
1Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Hand surgery & rehabilitation
|November 17, 2025
概括
在远距离半径骨折手术后早期开处方阿片类药物增加了阿片类药物未使用患者新的持续阿片类药物使用和长时间疼痛的风险. 这凸显了对替代性疼痛管理策略的需求.
科学领域:
- 整形外科手术 整形外科手术
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 距离半径骨折 (DRF) 是常见的,通常需要手术.
- 阿片类药物经常用于术后疼痛,但存在风险,特别是对于未使用阿片类药物的患者.
- 有关手术后新的持续性阿片类药物使用存在担忧.
研究的目的:
- 调查早期术后阿片类药物处方是否会增加在接受DRF手术的阿片类药物未使用患者中新持续阿片类药物使用的风险.
- 评估早期阿片类药物使用与持续的上肢疼痛之间的关联.
主要方法:
- 使用TrinetX数据库进行回顾性队列分析.
- 根据手术后处方,先前未使用过阿片类药物的患者分为阿片类药物和无阿片类药物组.
- 倾向性得分与混变量的控制匹配.
主要成果:
- 早期阿片类药物处方与新的持续阿片类药物使用 (4.2%对1.4%) 的风险显著增加有关.
- 在早期使用阿片类药物时,观察到持续前臂,手或手指疼痛 (1.0%vs. 0.6%) 和手腕疼痛 (5.8%vs. 3.8%) 的增加率.
- 没有发现死亡率或新精神健康障碍的显著差异.
结论:
- 在DRF手术后早期处方阿片类药物与新的持续阿片类药物使用和持续的上肢疼痛有关.
- 研究结果表明,需要谨慎的阿片类药物处方和探索替代性疼痛管理策略.
- 减少长期使用阿片类药物是DRF手术后疼痛管理的一个关键考虑因素.
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