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抑郁症中的反应性天体细胞相关的致病基因:一个多omics门德尔随机化研究

Peigang Fang¹, Shizhen Jia², Linsun Lin¹

¹Faculty of Chinese Medicine and State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao; Macau University of Science and Technology (M.U.S.T.) Innovation Technology Research Institute, Taipa, Macao.

Journal of affective disorders

|November 17, 2025

概括

反应性星球细胞及其基因,特别是LGALS3,PDGFA和GCDH,与抑郁风险有关. 这项研究揭示了特定的遗传和蛋白质关联,为抑郁症病原体提供了新的见解.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
分子生物学分子生物学

背景情况:

反应性星球细胞与抑郁症的发病有关.
涉及的特定基因及其分子机制在很大程度上是未知的.

研究的目的:

调查反应性天体细胞相关基因与抑郁症之间的关联.
确定特定的基因和分子通路,将反应性星球细胞与抑郁症联系起来.

主要方法:

综合定量特征位置数据 (mQTL,eQTL,pQTL) 与大规模抑郁GWAS.
采用了基于总结数据的门德尔随机化 (SMR) 和局部化分析.
使用大脑eQTL数据和CUMS小鼠模型验证的发现.

主要成果:

确定了130个甲基化位点,14个基因表达和3个与抑郁症有关的蛋白质关联.
发现LGALS3的高甲基化升高了LGALS3的表达,增加了抑郁症的风险.
在小鼠模型中确认了LGALS3的上调,并增加了星球细胞数量.

结论:

阐明了反应性星球细胞相关基因在抑郁症中的潜在参与.
突出了LGALS3,PDGFA和GCDH作为关键的兴趣基因.
提供了对反应性星体细胞在抑郁症中的作用的分子见解.

关键词:

通过DNA甲基化.抑郁症抑郁症抑郁症基因表达基因表达基因表达在LGALS3中门德尔的随机化多个omics的多个omics.反应性星球细胞反应性星球细胞.

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