在创伤后应激障碍中,大脑形态相似性网络的异常和调解效应
Zhuoman Xia1, Zhihong Cao2, Ting Li3
1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China.
Journal of affective disorders
|November 17, 2025
概括
创伤后应激障碍 (PTSD) 与大脑结构变化有关. 遗传风险因素影响这些变化,大脑结构调解了PTSD患者遗传风险和焦虑严重程度之间的关系.
科学领域:
- 神经成像是一种神经成像.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 创伤后应激障碍 (PTSD) 是一种复杂的多基因疾病.
- 了解PTSD遗传风险和大脑结构之间的相互作用至关重要.
研究的目的:
- 使用形态相似性网络 (MSN) 调查PTSD中的大脑结构变化.
- 探索多基因风险评分 (PRS) 对PTSD中大脑结构的调节效应.
- 检查大脑结构在遗传风险和临床症状之间的关系中扮演的调解角色.
主要方法:
- 对200名成年人 (52名PTSD,148名非PTSD) 和45名对照进行了结构性MRI扫描和基因测试.
- 构建了形态相似性网络 (MSN),并计算了多基因风险评分 (PRS).
- 用ANCOVA,线性回归和调解分析来评估MSN,PRS和临床/认知评估之间的关系.
主要成果:
- 创伤后应激障碍患者在多个皮质区域表现出异常的MSN值.
- 某些特定区域,如左带带状峡和右上边缘环,显示出较高的MSN值,而其他区域显示出较低的值.
- 右前骨的形态上相似的强度完全介导了PRS和焦虑严重程度之间的联系.
结论:
- 创伤后应激障碍与广泛的结构性大脑异常有关.
- 右前性MSN作为遗传风险和PTSD中的焦虑严重程度之间的关键调解者.
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