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Updated: Jan 11, 2026

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
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The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System

Published on: April 25, 2012

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现实世界药物监测和黄的临床风险:基于FAERS数据的不成比例性分析

Haifeng Wang1, Chang Xu2, Weiming Xie1

  • 1Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, 214151, China.

Journal of affective disorders
|November 17, 2025
PubMed
概括

这项研究分析了fluvoxamine安全数据,将精神疾病确定为常见不良事件 (AE). 它强调了以前未报告的副作用和药物相互作用,强调了对患者安全的临床警.

关键词:
不良事件是不良事件.公平的人是公平的.这种药物是fluvoxamine.

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The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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