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制定一个框架来评估诊断研究中目标条件的适用性

Eve Tomlinson¹, Jude Holmes², Anne W S Rutjes³

¹Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Journal of clinical epidemiology

|November 17, 2025

概括

在诊断测试准确性 (DTA) 审查中评估研究适用性是一项挑战. 我们开发了一个框架来指导作者评估QUADAS-2参考标准领域,提高DTA审查的可靠性.

科学领域:

医学研究方法论医学研究方法论.
证据综合研究
诊断准确性的研究研究.

背景情况:

评估初级研究的适用性至关重要,但在对诊断测试准确性 (DTA) 研究的系统审查中很困难.
QUADAS-2工具用于评估DTA审查中的偏见风险和适用性问题.
作者经常难以准确评估和报告适用性问题,特别是在参考标准领域.

研究的目的:

探讨如何审查作者评估适用性在考克伦DTA审查中的QUADAS-2参考标准领域.
在评估过程中确定常见的适用性问题和潜在问题.
制定一个框架,指导作者评估参考标准所定义的目标条件的适用性.

主要方法:

对于使用QUADAS-2并对参考标准域确定"高度关注"的Cochrane DTA审查的方法审查.
两个独立审稿人的"高度关注"适用性判断的理由的提取和主题分类.
基于提取的主题和专家讨论,开发一个适用性评估框架.

主要成果:

分析了50个符合条件的审查,揭示了五个主要主题的适用性问题.
关键问题包括不同的参考标准值,目标条件的错误分类以及提供的信息不足.
制定了一个框架,概述了四个潜在的适用性问题:目标条件子类别,值差异,参考标准的部分应用和错误分类.

结论:

虽然可识别可适用性问题的来源,但许多审查作者在评估和报告方面面临着挑战.
开发的框架为作者提供了指导,以改善对QUADAS参考标准领域内适用性问题的评估.
增强的适用性评估有助于更可靠和值得信赖的DTA审查.

关键词:

适用性适用性适用性诊断诊断诊断诊断是一个这就是QUADAS-2.参考标准是一个参考标准.系统性审查系统性审查目标条件目标条件

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