口腔环境改变对唾液菌负荷的影响:一项探索性临床研究
Kamis Gaballah1,2, Ensanya A Abou Neel3,4,5, Priyadharshini Sekar2
1Department of Oral and Craniofacial Health Sciences College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.
European journal of dentistry
|November 17, 2025
概括
牙科修复,如填充剂和皇冠显著增加了健康的唾液中的Candida albicans. 受影响的牙也会增加非白虫Candida的水平,受年龄和口腔卫生的影响.
科学领域:
- 口腔微生物学 口腔微生物学
- 牙科的生物材料
- 公共卫生 牙科 公共卫生 牙科
背景情况:
- 坎迪达菌种是常见的口服食用动物,但可以成为机会性病原体.
- 在健康人群中对口腔Candida殖民的研究是有限的.
- 在健康人群中了解影响液Candida负载的因素至关重要.
研究的目的:
- 调查口腔条件和牙科修复对健康个体唾液 Candida 负载的影响.
- 确定与增加的Candida殖民相关的特定口腔环境和社会人口统计因素.
- 为恢复性牙科的预防措施和材料选择提供见解.
主要方法:
- 从97名健康参与者中收集了唾液样本,分为五组,基于口腔条件.
- 参与者根据牙修复,假牙,舌头涂层或受损的牙被分类.
- 使用培养方法 (CFU/mL) 识别和量化了Candida物种.
主要成果:
- 在49.5%的样本中发现了Candida albicans,主要是在牙填充剂,牙冠或固定部分假牙的参与者中 (组2).
- 在67%的样本中检测到非白虫Candida (NAC),在受影响的牙的参与者中负载更高 (组5).
- 年龄,性别,种族,斑块和微积分得分显著影响了Candida负载;年长的男性和亚洲人有更高的水平.
结论:
- 牙科修复在健康个体中显著增加Candida albicans的唾液负载.
- 受影响的牙与较高的非白虫Candida负载有关.
- 年龄,口腔卫生和社会人口统计因素是唾液中Candida水平的关键预测因素,为预防策略提供了信息.
相关概念视频
01:26Assessment of the Mouth
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:20Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...