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相关概念视频

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Arteries of the Head and Neck01:26

Arteries of the Head and Neck

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The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
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Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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相关实验视频

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Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
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雾的动脉,偷偷的杀手.

Jacques D Barth1

  • 1Emeritus Professor of Cardiology, Keck School of Medicine, University of Southern California, Los Angeles, USA and the Vitide Medical Research Institute, Santa Monica, CA, USA.

Atherosclerosis
|November 17, 2025
PubMed
概括
此摘要是机器生成的。

细颗粒物 (PM2.5) 污染在全球显著增加缺血性心脏病 (IHD),不成比例地影响中等收入国家,男性和老年人. 迫切需要采取行动来减少空气污染及其心血管风险.

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A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
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科学领域:

  • 环境健康 环境健康
  • 心血管疾病流行病学
  • 空气污染研究研究

背景情况:

  • 环境细颗粒物 (PM2.5) 是一个新兴的全球健康问题.
  • 心血管疾病仍然是全球死亡的主要原因.
  • 之前的研究已经确定了空气污染和不良健康结果之间的联系.

研究的目的:

  • 从1990年到2021年,分析与环境PM2.5污染有关的缺血性心脏病 (IHD) 的全球负担.
  • 预测PM2.5相关的IHD的未来趋势.
  • 识别高风险人群和地区.

主要方法:

  • 利用了2021年全球疾病负担研究的数据.
  • 采用流行病学分析来评估历史和预计的IHD负担.
  • 审查了关于空气污染和心血管健康的基础研究.

主要成果:

  • 中等收入国家,男性和老年人承担着与PM2.5相关的IHD的不成比例负担.
  • 预计PM2.5对心血管健康的影响将大幅增加,到2025年可能与吸烟相匹配.
  • PM2.5的来源各不相同,包括来自车辆,工业,农业和家庭活动的排放.

结论:

  • PM2.5污染是缺血性心脏病的关键和日益增长的危险因素.
  • 综合战略是必要的,以减轻室外和室内空气污染.
  • 针对国内和跨境污染的政策干预对公共卫生至关重要.