老年人功能和认知表现:以NHANES为基础的甲基马龙酸作为线粒体功能障碍标志物的NHANES调解分析
Lijun Xia1,2, Yong Zhang3, Xiaoyang Lei1
1Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Renal failure
|November 17, 2025
概括
患有慢性病 (CKD) 的老年人可能会经历认知障碍. 由甲基马龙酸 (MMA) 水平表明的线粒体功能障碍部分解释了这种联系,表明MMA是潜在的认知衰退生物标志物.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學.
- 神经科学是一个神经科学.
背景情况:
- 慢性病 (CKD) 在老年人中普遍存在,并与认知障碍有关.
- 线粒体功能障碍 (MD) 与衰老和与年龄有关的疾病有关,但其在CKD相关认知衰退中的作用尚不清楚.
研究的目的:
- 调查老年人功能和认知功能 (CF) 之间的关联.
- 评估MD的调解作用,使用血清甲基马龙酸 (MMA) 作为生物标志物,在功能和CF之间的关系中.
主要方法:
- 来自2011-2014年国家健康和营养检查调查的2,437名60岁以上的参与者的数据分析.
- 评估CF使用动物流利性测试,CERAD单词学习测试和数字符号替换测试.
- 多变量线性回归和调解分析,检查功能,CF和血清MMA水平之间的关系.
主要成果:
- 在功能和CF之间发现了显著的积极关联 (β = 0.018,p < 0.001).
- 血清MMA水平显著介导了功能和CF之间的关系的13.33%.
- 功能对CF的直接影响和通过MMA的间接影响都具有统计学意义.
结论:
- 慢性病与美国老年人的认知障碍有关.
- 根据MMA水平的指示,MD部分调解了功能障碍对认知功能的有害影响.
- 在CKD的背景下,血清MMA可能作为认知障碍的潜在生物标志物.
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