结肠镜检查后益生菌对肠道微生物群的影响:一个多中心,随机,安慰剂控制的临床研究
Haoqi Wei1,2, Jue Wang3, Xiao Xiao4
1Department of Gastroenterology, the Second Affiliated Hospital, Army Medical University, Chongqing, China.
Journal of gastroenterology and hepatology
|November 17, 2025
概括
结肠镜检查后服用益生菌有助于恢复肠道微生物群的平衡,并减少腹部症状. 这种干预促进有益的细菌,改善胃肠道的健康后手术.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 临床研究 临床研究
背景情况:
- 结肠镜检查可以显著改变肠道微生物群的组成.
- 在结肠镜对肠道微生物群的确切影响方面存在有限的共识.
- 在手术后可能出现致病性细菌过度生长需要进行调查.
研究的目的:
- 评估益生菌在结肠镜检查后减轻肠道微生物群干扰方面的有效性.
- 评估益生菌对结肠镜后腹部症状的影响.
- 研究益生菌对肠道微生物群多样性和代谢途径的影响.
主要方法:
- 一个随机对照试验,涉及301名参与者.
- 益生菌组在结肠镜检查后接受了Bacillus Subtilis和Enterococcus Faecium囊,持续28天.
- 通过16S rRNA测序分析肠道微生物组成;使用GSRS评估症状严重程度.
主要成果:
- 结肠镜检查引发了肠道微生物群多样性的显著变化 (α和β).
- 益生菌干预丰富了有益的乳酸菌,改善了胃肠道症状评分表 (GSRS) 的得分.
- 益生菌组显示减少了腹部不适的持续时间和增强了葡萄糖代谢.
结论:
- 益生菌补充剂有效地抵消了结肠镜诱导的肠道微生物群变化.
- 益生菌促进有益的细菌转移,并改善相关的代谢功能.
- 在结肠镜后使用益生菌观察到腹部不适的早期改善.
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