在早期精神病中改变了语言通路的白质微观结构和语义认知缺陷
Werner Surbeck1, Wolfgang Omlor2, Noemi Dannecker2
1Department of Adult Psychiatry and Psychotherapy, Psychiatric Hospital of the University of Zurich, Zurich, Switzerland. werner.surbeck@pukzh.ch.
患有早期精神病的个体在语义控制方面表现出显著的缺陷,而不是语义表示. 这种语言功能障碍与弧形带的结构变化有关,这表明背部和腹部大脑通路之间的相互作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 语言学的语言学.
背景情况:
- 语义语言功能障碍是早期精神病的一个关键特征.
- 具体的大脑结构的相关性以及代表性或控制是否受损仍然不清楚.
研究的目的:
- 在早期精神病中区分语义表示和控制缺陷.
- 为了确定这些缺陷在腹部和背部语言通路中的结构性大脑相关.
主要方法:
- 调查了120个人 (40个早期精神病,40个高精神分裂型,40个低精神分裂型).
- 使用任务来隔离语义表示和控制性能.
- 采用手动纤维通道图谱的扩散张力成像 (DTI) 数据来分析腹部和背部通道的微观结构.
主要成果:
- 早期精神病组在语义控制方面表现出显著的缺陷,语义表征完好无损.
- 在早期精神病组中,左下面的前后和未结合的囊中较低的平均扩散度.
- 在左侧弧形囊中的分数异构性和早期精神病组中的语义控制性能之间的负相关性.
结论:
- 语义控制缺陷是早期精神病的一个核心特征.
- 弧形囊与语义控制有关,这表明综合的背腔腹流参与了语义处理.
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