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RAF 抑制剂通过直接激活 GCN2 来激活综合应激反应

Rebecca Gilley1, Andrew M Kidger2,3, Graham Neill4

  • 1Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. becky.gilley@babraham.ac.uk.

Nature communications
|November 17, 2025
PubMed
概括

矛盾的是,RAF抑制剂激活GCN2,一种压力激酶,独立于ERK1/2.2,启动综合应激反应 (ISR). 这种非目标效应可能会影响癌细胞对RAF抑制剂的反应.

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