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基于真实世界数据分析的腰椎间盘的内孔多利酶注射和手术治疗之间的成本和结果比较

Naoki Segi¹, Hiroaki Nakashima², Takahiro Imaizumi³

¹Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ward, Nagoya, 466-8550, Aichi, Japan.

Scientific reports

|November 17, 2025

概括

内孔多利酶注射疗法 (ICIT) 为腰椎椎间板 (LDH) 提供了一个具有成本效益的替代方案. 虽然ICIT的感染率较低,但它比传统的椎间盘切除需要更多的重复手术.

科学领域:

最少侵入性的脊柱手术
卫生经济学卫生经济学
相对有效性研究研究比较

背景情况:

腰椎间盘 (LDH) 是腰部疼痛的常见原因之一.
手术切除椎间盘是主要的治疗方法,但会带来风险和成本.
新的最小侵入性治疗方法,如内阴道酶注射疗法 (ICIT) 正在出现.

研究的目的:

为了比较不良事件,治疗结果和ICIT的成本与LDH的外科切除术.
通过健康主张数据评估ICIT的实际有效性和经济影响.

主要方法:

对2020-2023年健康声明数据的回顾性分析.
包括1982个ICIT病例,4009个内镜断层切除病例和5528个开放断层切除病例.
匹配对比ICIT与手术切除椎间盘组的对比.

主要成果:

与内镜和开放式切除术相比,ICIT显示手术部位感染率明显较低.
需要在90天内进行额外的脊椎手术的发生率在ICIT中显著高.
对ICIT的总治疗费用不到切术费用的50%.
ICIT显示,在治疗后的第一个月,止痛药的处方较少,但在治疗后的第三个月,处方较多.

结论:

内孔多利酶注射疗法 (ICIT) 是腰椎间盘 (LDH) 的可行,低成本的治疗选择.
虽然ICIT降低了感染风险和医疗保健成本,但其更高的重新手术率需要考虑.
进一步的研究应该探索长期的结果和ICIT患者的选择.

关键词:

行政数据管理数据诊断程序数据组合数据的诊断程序.椎间盘切除手术 (discectomy) 是一个切除椎间盘手术.健康声明数据健康声明数据数据内注射的康多利酶注射疗法腰椎椎间盘的发生

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