相关实验视频

Updated: Jan 11, 2026

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

花 (Chrysanthemum morifolium) 提取物通过调节脂质代谢来改善与代谢功能障碍相关的脂肪肝疾病

Wenjing Yu¹, Jun Qiu¹, Yonghu Chen¹

¹College of Pharmacy, Yanbian University Hospital, Yanbian University, Yanji, 133002, People's Republic of China.

Scientific reports

|November 17, 2025

概括

花 (Chrysanthemum morifolium,简称CM) 在小鼠中有效治疗与代谢功能障碍相关的脂肪肝疾病 (MAFLD). 它平衡脂质合成和氧化途径,为MAFLD提供了一个有前途的自然治疗方法.

科学领域:

肝病学肝病学是一种肝病学.
代谢疾病代谢疾病
药理学药理学是指药理学的学科.

背景情况:

代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个全球性的健康问题,治疗选择有限.
肝脂代谢失衡,包括合成和氧化,是MAFLD病变的核心原因.
关键的途径,SREBP-1c/FAS/ACCα (合成) 和PPARα/CPT-1 (氧化),对于MAFLD的发展至关重要.

研究的目的:

为了研究木木 (Chrysanthemum morifolium (CM)) 对MAFLD的治疗效果.
阐明CM及其化合物影响MAFLD脂质代谢的分子机制.

主要方法:

由脂质沉积诱导的MAFLD小鼠模型.
使用CM提取物及其分离化合物 (葡萄糖酸,六尼丁,葡萄糖酸-7-O-β-D-葡萄糖酸).
评估肝硬化,血清脂质概况 (TG,TC,LDL-C,HDL-C) 和关键通路的基因/蛋白质表达.

主要成果:

在MAFLD小鼠中,CM治疗显著减轻了肝肥胖症和改善了血清脂质概况.
服用CM降低了血清三糖化物 (TG),总胆固醇 (TC) 和低密度脂蛋白 (LDL-C),同时增加了高密度脂蛋白 (HDL-C).
CM的活性化合物调节了SREBP-1c/FAS/ACCα和PPARα/CPT-1通路,减少了脂质合成并增强了氧化.

结论:

花 (Chrysanthemum morifolium,CM) 在改善MAFLD方面表现出显著的疗效.
CM通过抑制SREBP-1c/FAS/ACCα通路和激活PPARα/CPT-1通路而起作用,恢复肝脏代谢平衡.
CM及其衍生化合物代表了MAFLD治疗的潜在治疗策略.

更多相关视频

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Published on: December 2, 2022

相关概念视频

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...