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Updated: Jan 6, 2026

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通过MSA工程和广泛的模型采样和CASP16中的排名来提高AlphaFold蛋白质三级结构预测

Jian Liu1,2, Pawan Neupane1,2, Jianlin Cheng3,4

  • 1Department of Electrical Engineering & Computer Science, University of Missouri, Columbia, MO, USA.

Communications biology
|November 17, 2025
PubMed
概括

通过改进多个序列对齐生成和模型采样,MULTICOM4提高了对具有挑战性的目标的蛋白质结构预测. 这种集成系统提高了AlphaFold预测的准确性,有助于结构生物学和药物发现.

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