新生儿脑病和神经发育结果中的MRI评分系统:系统性审查
Emma Finnegan1, Alexandre Assi1, Ella Carroll1
1Discipline of Paediatrics, School of Medicine, Trinity College Dublin, the University of Dublin, Dublin, Ireland.
概括
针对新生儿脑病 (NE) 的新生儿大脑MRI评分系统显示,对婴儿神经发育结果的预测准确度类似. 简单的系统,如NICHD,与复杂的系统一样有效,提供临床效率.
科学领域:
- 新生儿科学 新生儿科学
- 神经成像是一种神经成像.
- 发育儿科 发育儿科
背景情况:
- 新生儿大脑MRI对于诊断新生儿脑病变 (NE) 是至关重要的.
- 目前的神经成像缺乏标准化的评分系统来预测受影响婴儿的神经发育结果.
- 这种差距阻碍了一致的预后和临床管理.
研究的目的:
- 系统地审查和评估现有的新生儿MRI评分系统对NE的预测性能.
- 评估MRI得分与预产婴儿神经发育结果之间的相关性.
- 确定临床使用中最有效和高效的评分系统.
主要方法:
- 按照柯克兰和PRISMA指南进行系统审查,并注册在PROSPERO.
- 包括专注于怀孕≥36周出生婴儿与NE和神经发育随访的研究.
- 评价分数系统:NICHD,Rutherford,Weeke,Trivedi,Barkovich,以及一个新的分数.
主要成果:
- 涉及1925名参与者的16项研究符合纳入标准.
- 15项研究表明,MRI得分与神经发育结果之间存在显著的关联.
- 所有评估的MRI评分系统都表现出可比的预测准确度;像NICHD这样的简单系统的性能与复杂系统相似.
结论:
- 现有的新生儿MRI评分系统在NE中显示了类似的神经发育结果的预测能力.
- 简单的评分系统,如NICHD,提供与更复杂的系统可比的准确性.
- 这些发现表明,更简单的MRI评分系统可能是新生儿脑病的临床应用中更有效的选择.
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