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结性脊柱炎的肠骨轴:机械学见解和翻译差距

Xuhong Zhang¹, Lu Jia¹, Xueni Lin¹

¹Department of Rheumatology, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, WuXi, China.

Clinical and experimental medicine

|November 17, 2025

概括

结性脊柱炎 (AS) 治疗是复杂的,因为疾病的可变性. 建议使用人工智能进行个性化,生物标志物驱动的疗法,通过解决肠-骨轴来改善结果.

科学领域:

免疫学免疫学免疫学
胃肠病学胃肠病学
类风湿病学类风湿病学

背景情况:

肠-骨轴,包括肠道失调和免疫激活,是结性脊髓炎 (AS) 发病的关键.
将这些发现转化为有效的AS治疗方法是具有挑战性的.

研究的目的:

分析AS治疗中的翻译差距.
用当前的治疗方法解释治疗悖论.
为AS提出一个新的个性化治疗框架.

主要方法:

对AS中肠骨轴的现有文献进行批判性审查.
对细胞因子抑制剂 (IL-23,IL-17) 和微生物组疗法的临床数据的分析.
关于人工智能辅助的,基于生物标志物驱动的治疗策略的建议,整合多原子数据.

主要成果:

用细胞因子抑制剂和微生物组向治疗的治疗悖论源于AS疾病的变异性.
IL-23抑制剂的意想不到的失败和IL-17阻断的双重效应凸显了了解组织特异性免疫的必要性.
需要个性化的方法来弥合机制理解和临床成功之间的差距.

结论:

解决AS变异性对于治疗成功至关重要.
一个以生物标志物驱动的,人工智能辅助的框架,整合多原子数据,可以个性化AS治疗.
这种方法旨在在结性脊柱炎中实现无进展的缓解.

关键词:

结性脊柱炎是一种疾病.人工智能的人工智能是人工智能.细胞因子抑制剂的作用肠 - 骨轴肠 - 骨轴微生物组调制是微生物组的调制.精准医学是一门精准的医学.

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