测试PASC分数:长期COVID诊断中的临床与统计准确性
Alba Azola1,2, Raha M Dastgheyb3, Rebecca Easter3
1Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. aazola1@jhmi.edu.
Journal of general internal medicine
|November 17, 2025
概括
复原SARS-CoV-2感染的急性后续 (PASC) 评分显示了长期COVID (LC) 诊断的高特异性,但需要提高灵敏度. 特定的症状组合为LC提供了更好的诊断准确性.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 长期COVID (LC) 是一个重大的公共卫生挑战,具有多样化和持久的症状.
- 准确的诊断工具对于识别LC和促进及时的患者护理至关重要.
- 复原SARS-CoV-2感染的急性后续 (PASC) 评分是帮助LC诊断的工具.
研究的目的:
- 在一组长期COVID患者中验证现有的RECOVER PASC得分.
- 评估和改进PASC评分对LC诊断的敏感性和特异性.
- 将PASC分数的表现与国家科学,工程和医学院 (NASEM) 的表现进行比较 2024 LC定义.
主要方法:
- 一项涉及130名符合NASEM 2024 LC定义的患者和60名恢复的对照的横截面研究.
- 参与者完成了全面的调查,以计算PASC分数并评估症状的存在.
- 包括灵敏度,特异性和正预测值 (PPV) 在内的评估指标是通过将PASC分数与NASEM定义进行比较来计算的.
主要成果:
- 恢复PASC得分显示高特异性 (100%) 和PPV (100%),但敏感性有限 (80%),缺少20%的LC病例.
- 特定症状的组合 (嗅觉/味觉丧失,运动后不适或性功能障碍) 显示出性能改善:94%的灵敏度,92%的特异性和96%的PPV.
- 瘤癌的诊断和PASC得分有显著的相关性 (χ2 = 102.99,P < 0.001).
结论:
- 恢复PASC得分是长期COVID诊断的有用工具,尽管需要进一步改进.
- 持续努力更新LC定义并开发实用的临床诊断工具是必不可少的.
- 需要国家倡议,为长期COVID诊断创建易于实施的临床工具.
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