相关实验视频

Updated: Jan 11, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

血清miR-493-3p作为诊断生物标志物和表观遗传调节剂,向儿童急性淋巴细胞白血病中的DPY30

Hong Yang¹, Yong Xu², Xiaoying Zhang³

¹Department of Pediatrics, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, 100074, China.

Annals of hematology

|November 17, 2025

概括

血清微RNA-493-3p (miR-493-3p) 在儿科急性淋巴细胞白血病 (ALL) 中降低调节. 较低的miR-493-3p水平表明预后不佳,可以帮助诊断ALL,表明潜在的治疗点.

科学领域:

儿科瘤学儿科瘤学
分子生物学分子生物学
生物标志物发现发现

背景情况:

儿科急性淋巴细胞白血病 (ALL) 是最常见的儿童癌症.
确定可靠的生物标志物对ALL的诊断和预后至关重要.

研究的目的:

为了研究血清microRNA-493-3p (miR-493-3p) 在儿科ALL中的诊断价值.
探索miR-493-3p在ALL病变发生中的功能作用.

主要方法:

在103名ALL患者和85名健康对照中,使用qRT-PCR量化血清miR-493-3p水平.
生物信息分析和双露西法酶记者测定确定DPY30为miR-493-3p的直接目标.
功能性实验评估了miR-493-3p和DPY30对白血病细胞表型的影响.

主要成果:

在ALL患者中,血清miR-493-3p显著下调 (AUC=0.881),并与高级风险和低生存率相关.
miR-493-3p直接针对DPY30,在临床样本中观察到的反相关性.
过度表达miR-493-3p抑制了扩散和入侵,并通过向DPY30在ALL细胞中促进了细胞亡.

结论:

血清miR-493-3p是一种有前途的非侵入性生物标志物,用于儿科ALL诊断和预后.
在ALL中,miR-493-3p/DPY30轴作为瘤抑制机制起作用.
准miR-493-3p/DPY30通路可能为ALL提供一种新的治疗策略.

关键词:

急性淋巴细胞白血病 (Acute Lymphoblastic Leukemia) 是一种急性淋巴细胞白血病.DPY3030 是一个很好的项目.诊断诊断诊断诊断诊断在 MiR-493-3p 中使用.预测预后预测预测

更多相关视频

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

相关概念视频

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...