肺癌查中的液体活检:理由,进展,机遇和挑战
Caizheng Li1, Hongtao Jiang2, Xiaoran Sun3
1General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, No. 37 Guoxuexiang Road, Chengdu, 610041, Sichuan, China.
Clinical and experimental medicine
|November 17, 2025
概括
液体活检显示了非侵入性肺癌 (LC) 查的前景,为低剂量计算机断层扫描 (LDCT) 提供了准确的替代方案. 本综述探讨了将液体活检整合到临床实践中的生物标志物和技术,以改善LC结果.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 非侵入性诊断是一种非侵入性诊断.
背景情况:
- 肺癌 (LC) 是全球癌症死亡的主要原因.
- 目前的查方法,如低剂量计算机断层扫描 (LDCT) 有局限性.
- 液体活检为早期LC检测提供了一个非侵入性的替代方案.
研究的目的:
- 审查肺癌查液体活检的最新进展.
- 评估液体活检生物标记物的生物学相关性,准确性和检测技术.
- 探索液体活检在临床实践中的整合,以改善患者的治疗结果.
主要方法:
- 对当前的液体活检技术进行文献综述 LC.
- 对循环瘤DNA,蛋白质和代谢物生物标志物的分析.
- 评估成本效益和临床整合策略.
主要成果:
- 液体活检生物标志物证明了精确的LC检测的潜力.
- 各种检测技术正在为临床应用而发展.
- 具有成本效益的整合策略对于广泛采用至关重要.
结论:
- 液体活检是一种有前途的非侵入性工具,用于早期检测肺癌.
- 需要进一步的研究来优化生物标志物面板和检测方法.
- 成功融入临床实践可以显著改善LC的结果.
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