在老年人血管队列中,动脉狭窄与处理速度和执行功能的认知缺陷有关,这与p-tau217相关
Summan Zahra1, Scott R French1, Juan C Arias1
1The Division of Vascular Surgery, University of Arizona, Tucson, Arizona, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|November 17, 2025
概括
无症状的外动脉动脉样硬化病 (aECAD) 与认知能力下降有关,特别是在处理速度和执行功能方面. 这种血管状况也与阿尔茨海默病的生物标志物如p-tau217.7相关.
科学领域:
- 神经学 神经学
- 血管医学 血管医学
- 认知科学 认知科学
背景情况:
- 无症状的外动脉动脉样硬化疾病 (aECAD) 越来越多地被认为是导致认知障碍的潜在因素,包括阿尔茨海默病 (AD).
- 然而,与aECAD相关的特定早期认知缺陷仍然不明,特别是在具有多个血管风险因素的个体中.
研究的目的:
- 调查无症状外冠状动脉样硬化疾病 (aECAD) 患者最早的认知缺陷.
- 探索认知功能,动脉狭窄症严重程度和阿尔茨海默病生物标志物之间的关系.
主要方法:
- 年龄在50-85岁之间,患有血管并发症的182名参与者,有或没有ECAD,接受了神经认知测试.
- 评估包括处理速度,执行功能和化 (p-tau217) 的评估.
- 排除标准包括痴呆症,最近的中风和其他神经系统疾病.
主要成果:
- aECAD与处理速度和执行功能的表现差显著相关,即使调整了人口和血管因素.
- 从这些测量结果中得出的新型动脉认知指数与血p-tau217水平有很强的相关性.
- 这些发现独立于白质病变和阿波利波蛋白E (APOE) ε4状态.
结论:
- 处理速度和执行功能的特定认知障碍与动脉狭窄有关.
- 这些与血管相关的认知缺陷可能与阿尔茨海默病典型的记忆障碍相辅相成或相反.
- 需要进一步的研究来阐明血管健康和认知衰退中的神经退行过程之间的相互作用.
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