双菌 (Bifidobacterium bifidum FB3-12) 通过增强肠道屏障功能和调节肠道微生物群来减轻卵素诱导的过敏疾病
Ruixin Kou1, Ang Li1, Miao Yu1
1Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin, 300071, China.
NPJ science of food
|November 17, 2025
概括
Bifidobacterium bifidum FB3-12通过改善肠道健康和恢复免疫平衡,有效地减少了小鼠的过敏症状. 这种益生菌菌株显示出通过微生物组调节治疗过敏疾病的前景.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 过敏性疾病对全球健康构成重大挑战,环境变化加剧了这一问题.
- 双菌 (B. bifidum) 显示出对过敏管理的潜力,因为它对肠道微环境产生积极影响.
研究的目的:
- 在卵蛋白 (OVA) 诱导过敏小鼠模型中研究B. bifidum菌株FB3-12的抗过敏作用.
- 探索FB3-12治疗潜力的基础机制,重点关注免疫反应和肠道微生物组调节.
主要方法:
- 用OVA诱导的过敏小鼠模型来评估三周FB3-12肠道干预的疗效.
- 分析了关键的免疫标记物 (OVA特异性IgE,Mcpt-1,基因组胺),Th2/Th1平衡,肠道完整性 (Mucin-2,紧结蛋白),肠道微生物群组成和短链脂肪酸 (SCFA).
主要成果:
- FB3-12治疗显著降低了OVA特异性IgE,Mcpt-1和组胺的血清水平,同时恢复了Th2/Th1免疫平衡.
- 用FB3-12改善了肠损伤和炎症,增加了Mucin-2和紧结蛋白表达.
- 干预FB3-12调节了肠道微生物群,增加了有益的属 (Lactobacillus,Colidextribacter),使Firmicutes/Bacteroidetes比率正常化,并提高了SCFA和GPRs的调节.
结论:
- 在小鼠模型中,B. bifidum FB3-12显示出显著的抗过敏潜力.
- FB3-12通过调节肠道微生物群来缓解过敏症状,增强肠道屏障功能,并重新平衡免疫反应.
- 这种菌株对治疗应用和预防过敏性疾病充满希望.
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