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Updated: Jan 11, 2026

qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
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qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes

Published on: March 6, 2019

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非洲祖先特异变种IKKβ p.Glu502Lys赋予高狼风险

Gudny Ella Thorlacius1, Erna V Ivarsdottir2, Saedis Saevarsdottir2,3,4

  • 1Amgen deCODE Genetics, Reykjavik, Iceland. gudny.thorlacius@decode.is.

Nature genetics
|November 18, 2025
PubMed
概括

一种罕见的基因变异,IKKβE502K,在非洲祖先的个体中显著增加皮肤性红斑狼 (CLE) 和全身性红斑狼 (SLE) 的风险. 这一发现强调了在遗传狼研究中多样化的种群的重要性.

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