循环和血压之间的剂量反应关联:系统性审查和元分析
Homa Khodadadi1,2, Amirhossein Ebrahimi1,2,3, Fatemeh Jalali1,2
1Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
BMC public health
|November 18, 2025
概括
这项研究发现水平与高血压风险之间存在U形联系. 高或低可能会增加高血压风险,特别是在女性中,这需要进一步调查.
科学领域:
- 营养流行病学 营养流行病学
- 心血管健康的心血管健康
背景情况:
- 高血压是全球主要的健康问题,患病率不断增加.
- 目前关于循环与高血压风险之间的关联的研究是不一致的.
研究的目的:
- 系统地审查和分析循环水平与高血压风险之间的关系.
- 进行剂量反应分析以澄清关联.
主要方法:
- 在2023年12月之前,对主要数据库 (Medline/PubMed,Scopus,Web of Science,Google Scholar) 进行系统搜索.
- 包括17项观察性研究,涉及28312名参与者.
- 使用随机效应模型进行元分析,以计算总结相对风险 (RR) 和95%置信区间 (95% CI).
- 评估非线性和线性剂量反应关系.
主要成果:
- 在最高和最低的循环和高血压风险之间没有显著的总体关联 (RR: 1.15;95% CI: 0.99-1.33).
- 亚组分析显示,在水平最高和最低的女性中,高血压风险增加了36% (95% CI:1.03-1.81).
- 非线性剂量反应分析表明,循环和高血压风险之间存在U形关联 (P < 0.001).
结论:
- 在成年人中,循环和高血压风险之间存在U形关联.
- 需要进一步的前性研究来确定因果关系并阐明潜在的机制.
更多相关视频
09:29Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
Published on: March 5, 2019
6.0K
09:56Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
5.8K
相关概念视频
Hypertension and Regulation of Blood Pressure
3.6K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.6K
Blood Pressure
4.1K
Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
4.1K
Blood Pressure
9.3K
The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
9.3K
Disorders of the Autonomic Nervous System
1.4K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
1.4K
Hormonal Regulation of Blood Pressure
5.8K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
5.8K
Factors affecting Blood pressure
6.3K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
6.3K
