最近,库克县的A组链球菌Pyogenes相关死亡人数上升:一个案例系列
Samantha Stephen1, Benjamin J Soriano1, Lorenzo Gitto1,2
1Department of Pathology, Cook County medical Examiner's Office, Chicago, Illinois.
在COVID-19后,A组链球菌 (GAS) 感染急剧增加,导致法医鉴定出致命病例的增加. 法医病理学对于诊断这些严重的GAS感染和帮助公共卫生工作至关重要.
科学领域:
- 微生物学 微生物学
- 病理学 病理学 病理学
- 公共卫生 公共卫生
背景情况:
- 甲型链球菌 (GAS) 引起轻度至重度的入侵性疾病.
- 在COVID-19大流行后观察到侵入性GAS感染的显著增加.
- 库克县法医办公室 (CCMEO) 的致命GAS病例显示,流行后出现了显著的激增.
研究的目的:
- 在CCMEO分析2015-2025年致命的A组链球菌病例.
- 评估快速抗原测试在儿科病例中用于死后GAS诊断的实用性.
主要方法:
- 追溯审查26个致命的GAS病例 (2015-2025年).
- 使用无菌部位培养和组织学进行死后诊断.
- 用快速抗原测定和培养对儿科死后喉拭子的测试.
主要成果:
- 在流行病后的时期观察到致命的GAS病例的显著增加.
- 大多数确诊的GAS病例呈现出快速进展和高死亡率.
- 儿科喉拭片的快速抗原测定结果是负的,通过培养得到证实.
结论:
- 法医病理学家在识别和记录侵入性GAS感染方面发挥着至关重要的作用.
- 研究结果表明,快速抗原测试可能有助于排除在阴性儿科病例中的GAS.
- 警和准确的诊断对于减少GAS发病率和死亡率至关重要.
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