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加多对合成磁共振定量成像的作用
Lenka Novakova1,2, Igal Rosenstein1,2, Markus Axelsson1,2
1Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
概括
在多发性硬化症患者中,加多对比物会影响大脑体积,改变诸如白质量和灰质量等尺度. 在纵向研究中,在结合对比前和后合成MRI指标时,建议谨慎使用.
科学领域:
- 放射学 放射学是一门学科.
- 神经成像是一种神经成像.
- 量化MRI是指数量化的MRI.
背景情况:
- 合成 (Sy) MRI 提供使用T1加权,T2加权和质子密度放松计的定量测量.
- 加多 (Gd) 对比剂在MRI中使用,通过改变放松时间来检测多发性硬化症患者 (PwMS) 的活跃病变.
研究的目的:
- 评估Gd对比剂在PwMS中对SyMRI衍生体积测量的影响.
- 为了比较Gd对比对PwMS和健康对照之间的大脑体积学的影响.
主要方法:
- 106名PwMS和15名对照在3T扫描仪上进行了对比前和后的大脑SYMRI.
- 评估了大脑辅酶体分数 (BPF),白质 (WM),灰质 (GM),髓 (Myl),非水性成分 (NAC),过量的辅酶体水 (EPW) 和T1增强 (T1E) 的变化.
- 统计分析包括配对和独立的样本t测试.
主要成果:
- Gd对比剂的使用导致了PwMS和对照组的显著体积变化,包括BPF,WM,Myl,NAC,EPW的增加,GM的减少.
- T1增强 (T1E) 显示PwMS显著增加 (p < 0.001),但对照组没有显著增加 (p = 0.76).
- 在PwMS中与T1E相关的对比增强病变的数量 (r = 0.348,p < 0.003).
结论:
- 在Gd对比剂给药后,在PwMS和对照组中观察到体积变化的一致模式.
- T1E变化表明,Gd对比可能会特别影响PwMS的结果.
- 在PwMS的纵向研究中结合对比前和后的SyMRI指标,由于潜在的对比效应,需要仔细解释.
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