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隐形眼镜消毒剂对导致结膜炎的包裹和非包裹病原性病毒的杀菌作用
Weiyin Hu1, Hiroshi Shimoda, Daisuke Hayasaka
1Laboratory of Veterinary Microbiology (W.H., H.S., D.H.), Department of Veterinary Medicine, Joint Graduate School of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan; Laboratory of Veterinary Microbiology (H.S., D.H.), Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan; and Division of Pathogenic Microorganism (H.S., D.H.), Research Center for Thermotolerant Microbial Resources, Yamaguchi University, Yamaguchi, Japan.
酸盐和过氧化接触镜片消毒剂有效地杀死包裹的SARS-CoV-2和非包裹的人类腺病毒. 其他消毒剂对人类腺病毒的有效性有限,这凸显了适当的隐形眼镜护理的重要性.
科学领域:
- 眼科医生 眼科 眼科
- 病毒学 病毒学
- 微生物学 微生物学
背景情况:
- 隐形眼镜 (CL) 的污染构成病毒性角质结膜炎传播的风险.
- 人类腺病毒 (HAdV-D) 和SARS-CoV-2可以引起眼睛感染,原因是消毒剂的消毒和病毒稳定性不充分.
研究的目的:
- 评估商业CL消毒剂对HAdV-D和SARS-CoV-2的抗病毒疗效.
- 确定有效的消毒剂,以防止通过隐形眼镜传播病毒.
主要方法:
- 在细胞系中评估了CL消毒剂的细胞毒性.
- 病毒用消毒剂进行化,遵循制造商的协议.
- 感染性病毒标位在化后确定,并与对照组进行比较.
主要成果:
- 低酸和过氧化消毒剂使SARS-CoV-2和HAdV-D56.2两种病毒都失活.
- 酸和一些基于PHMB的消毒剂禁用了SARS-CoV-2,但没有HAdV-D56.
- 其他消毒剂 (PHMB,e-polylysine,PQ-1,alexidine化物) 对这两种病毒的有效性有限.
结论:
- 基于酸盐和过氧化的CL消毒剂显示出强大的杀毒活性,对包裹和非包裹病毒.
- 人类腺病毒是结膜炎的重要原因.
- 建议使用制造商协议每天消毒隐形眼镜.
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