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欧核生物基因调节的风景和不平衡波动

Masaki Sasai^1,2, Bhaswati Bhattacharyya³, Shin Fujishiro¹

¹Kyoto University, Fukui Institute for Fundamental Chemistry, Kyoto 606-8103, Japan.

Physical review. E

|November 18, 2025

概括

慢慢的染色质状态变化显著影响了真核生物中的基因调节动态. 这种时间尺度的差异影响了转录活动和基因波动,揭示了复杂的调节机制.

科学领域:

系统调节的物理学系统调节的物理学
分子和细胞生物学分子和细胞生物学
生物物理学的生物物理.

背景情况:

了解跨不同时间尺度的流程对于系统监管至关重要.
在基因调节中,不同染色质状态和蛋白质度的时间尺度对分析合动态提出了挑战.

研究的目的:

研究时间尺度差异对真核生物基因调节的影响.
为了探索非adiabatic染色体状态转换对基因表达动态的影响.

主要方法:

开发了一个不平衡波动,概率流和景观的随机模型.
模拟循环概率电流以分析产量.
在小鼠胚胎干细胞中建模了一个三核基因电路.

主要成果:

研究人员发现,缓慢的,非adiabatic的染色体状态转换显著影响基因调节.
在高强度非性疗法中,在低染色体状态过渡率下发生最大的产生.
轻度非亚迪亚巴的疗法表现出歇斯底里,这表明染色质的变化先于转录活动.

结论:

非附加性染色体状态转换为真核细胞基因调节带来了丰富的动态.
时间尺度的差异可以调整基因特异性波动,如小鼠胚胎干细胞模型所示.
该研究提供了对基因调节网络时间尺度的复杂相互作用的见解.

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