2型糖尿病患者认知障碍的危险因素 2型糖尿病患者认知障碍的危险因素
Asieh Mansour1, Camellia Akhgarjand2, Athena Dehghan Najm Abadi3
1Endocrinology and Metabolism Research Centre, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Journal of diabetes and metabolic disorders
|November 18, 2025
概括
认知障碍在2型糖尿病 (T2DM) 中很常见. 糖尿病持续时间较长,特别是超过8.5年,显著增加T2DM患者认知能力下降的风险.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
- 认知障碍是T2DM的常见并发症.
- 识别T2DM认知障碍的危险因素对于及时干预至关重要.
研究的目的:
- 调查T2DM成年人认知障碍的危险因素.
- 建立预防和治疗T2DM患者认知衰退的基础.
主要方法:
- 对患有T2DM的成年人 (≥18岁) 和现有的实验室数据进行横截面研究.
- 排除患有严重认知或神经障碍的个人.
- 使用蒙特利尔认知评估 (MoCA) 评估认知功能;得分<26表示损伤.
主要成果:
- 在229名参与者中,93% (213) 的人表现出认知障碍.
- 糖尿病持续时间较长与认知障碍独立相关 (OR:1.188,P=0.007).
- 预测认知障碍的最佳持续时间值为8.5年 (AUC:0.693).
结论:
- 增加糖尿病持续时间是T2DM认知障碍的重要危险因素.
- 糖尿病每增加一年,就会使认知能力下降的几率增加18%.
- 建议对超过8.5岁的糖尿病患者进行认知监测,以早期发现和干预.
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