与IgG4相关的疾病:一系列病例突出了不同的临床表现和治疗结果
Thanda Aung1, Kaitlin Eblen1, Gregory A Fishbein2
1Rheumatology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Cureus
|November 18, 2025
概括
与免疫球蛋白G4相关的疾病 (IgG4-RD) 呈现出各种症状,通常模仿其他疾病. 在IgG4-RD患者中,早期考虑和Rituximab治疗显示出有前途的结果.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 免疫球蛋白G4相关疾病 (IgG4-RD) 是一种罕见的全身纤维炎症疾病.
- 它的特征是器官胀,IgG4阳性血细胞透和纤维化.
- IgG4-RD可以影响多个器官,并表现出各种症状,造成诊断挑战.
研究的目的:
- 突出IgG4-RD的不同临床表现.
- 讨论与IgG4-RD相关的诊断挑战.
- 为IgG4-RD提出成功的管理方法.
主要方法:
- 三名患有IgG4-RD的患者的病例系列介绍.
- 详细描述临床表现,诊断工作和治疗.
- 对诊断考虑和管理策略的审查.
主要成果:
- 案例1:一个45岁的女性,眼和唾液腺透,模仿Sjögren综合征.
- 案例2:一名77岁的男性患有胰腺质量,中腔血管炎和淋巴腺病,怀疑是胰腺癌.
- 案例3:75岁的男性患有扩散性淋巴腺病,最初怀疑是淋巴瘤. 所有患者都对Rituximab治疗反应良好.
结论:
- 需要考虑IgG4-RD在非典型表现的多系统疾病的差异诊断.
- 利图西马布是IgG4-RD的有效治疗选择,导致显著的临床和放射性改善.
- 早期诊断和适当的治疗对于IgG4-RD的良好结果至关重要.
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