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Grace S Lach^1,2, Farrah N Brown^1,2, Ariel E Lee^1,2

¹Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.

|November 18, 2025

概括

过多的生长激素 (GH) 会促进组织纤维化,特别是在老年小鼠中. 这项研究研究了多种组织和年龄的纤维化,揭示了与年龄相关的原沉积的增加以及对GH的反应中的特定性别差异.

科学领域:

内分泌学在内分泌学.
病理学病理学病理学
动物模型动物模型

背景情况:

纤维化,以过度的细胞外基质沉积为特征,损害组织功能.
巨和与之相关的生长激素 (GH) 和类似胰岛素的生长因子-1 (IGF-1) 信号传递与纤维化有关.
缺乏GH诱导纤维化的综合多组织和基于年龄的分析.

研究的目的:

评估6个组织 (肺,脏,肝脏,脏,四头骨,心脏) 的纤维化,年轻和老年牛GH (bGH) 转基因和野生型小鼠.
评估年龄,性别和GH过剩对原蛋白含量和营业额的影响.

主要方法:

氧氨酸含量测定量化原蛋白.
皮克罗西里乌斯红色 (PSR) 染色用于原可视化.
血清生物标志物 (PINP,ICTP,FAP) 用于评估原体的周转率.

主要成果:

随着年龄的增长,原蛋白含量在所有组织和性别中显著增加.
年龄较大的雄性bGH小鼠在肺,,肝脏和四头骨中显示出高原;年龄较大的雌性在,肝脏和四头骨中显示出增加.
在老年bGH小鼠中,PSR染色揭示了纤维化增加,具有性别特异的模式,而血清生物标志物表明了特定于年龄和性别的原循环变化.

结论:

过多的GH在大多数研究的组织中显著促进纤维化,随着年龄的增长,效应变得更加明显.
纤维化是GH过量的常见结果,尽管直接因果关系与次要影响需要进一步调查.
年龄和性别是调节GH诱导纤维化反应的关键因素.

关键词:

衰老的衰老衰老的衰老在bGH小鼠中.原蛋白是一种原蛋白.纤维化纤维化增长激素增长激素的使用方法

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