在多发性硬化症中疲劳的网络定位
Olli Likitalo1,2,3, Jaakko Kungshamn1,2,3, Albert Bellmunt-Gil1
1Clinical Neurosciences, Turku Brain and Mind Center, University of Turku, Turku, Finland.
Annals of clinical and translational neurology
|November 18, 2025
概括
多发性硬化症 (MS) 的疲劳与大脑网络有关,而不是特定的病变部位. 损伤与前运动皮层的连接性与MS疲劳严重程度有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 疲劳是多发性硬化症 (MS) 的普遍症状,严重影响患者的生活质量.
- 与MS相关的疲劳的精确神经生物学基础仍然不完全理解.
- 这项研究通过检查病变位置及其连接模式来调查与MS患者疲劳相关的大脑网络.
研究的目的:
- 确定与多发性硬化症 (MS) 疲劳相关的特定大脑网络和神经基质.
- 探索MS患者的病变连接性和疲劳严重程度之间的关系.
- 为了确定已识别的MS疲劳网络是否可在其他神经疾病中复制,如中风.
主要方法:
- 用voxel损伤症状映射和损伤网络映射来分析损伤-症状关联.
- 该研究包括38名患有疲劳的多发性硬化症患者和21名没有疲劳的多发性硬化症患者,研究结果在两个独立数据集中得到验证 (199名多发性硬化症患者,85名中风患者).
- 休息状态功能连接MRI (rs-fcMRI) 用于一个验证数据集.
主要成果:
- 没有特定的解剖病变位置与MS的疲劳直接相关.
- 与疲劳相关的病变显示出与网络的连接,峰值在右前运动皮质,负面与左极.
- 从前运动皮层到其他大脑区域的连接与MS疲劳严重程度相关,并且在中风后的疲劳中可重现.
结论:
- 多发性硬化症 (MS) 的疲劳局限于特定的大脑网络,而不是孤立的病变部位.
- 损伤连接,特别是涉及前运动皮质,是MS疲劳的关键神经基质.
- 这些发现为驱动MS和相关疾病疲劳的神经生物学机制提供了关键的见解.
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