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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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The Extracellular Matrix01:29

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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
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肌再生中的脱细胞化细胞外矩阵 (dECM):综合性审查

Kumaresan Sakthiabirami1, Yeonwoo Park2, Seong Kyeong Jo1

  • 1Department of Orthopedic Surgery, Konyang University Hospital, Daejeon, 35365, Republic of Korea.

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概括
此摘要是机器生成的。

脱细胞化外细胞矩阵 (dECM) 支架通过模仿自然环境和增强愈合,对肌组织工程有很大的希望. 本综述探讨了dECM策略及其临床应用的潜力.

关键词:
脱细胞化细胞外基质 (dECM)制造技术 制造技术脚手架的脚手架是一个脚手架.肌受伤和愈合的过程肌再生 肌再生

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科学领域:

  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.
  • 整形外科手术 整形外科手术

背景情况:

  • 肌损伤由于其复杂的结构和自然愈合能力差,因此存在重大临床挑战.
  • 原生肌微环境对于有效的组织再生至关重要.
  • 目前的治疗方法往往导致功能恢复不足于最佳水平.

研究的目的:

  • 审查细胞外矩阵 (ECM) 在肌愈合中的作用.
  • 总结目前用于ECM的脱细胞化方法.
  • 探索脱细胞化ECM (dECM) 与肌组织工程的新兴技术的整合.

主要方法:

  • 关于脱细胞化技术的文献综述.
  • 分析dECM脚手架制造方法,包括3D打印,混合复合材料和水凝.
  • 对dECM支架疗效的临床前数据的评估.

主要成果:

  • 脱细胞化ECM (dECM) 支架有效地复制了本地肌微环境.
  • 与3D打印等技术的整合提高了脚手架的设计和功能.
  • 临床前研究表明dECM在促进肌再生方面取得了有希望的结果.

结论:

  • 基于dECM的支架是肌组织工程的一个有希望的策略.
  • 为了临床应用,需要进一步的研究和解决翻译挑战.
  • 这些先进的支架具有显著的潜力,可以改善肌修复的临床结果.