ACE I/D和ACE2之间的关联rs2285666 多态与COVID-19疾病严重性
Sepideh Drikvand1, Mehdi Ajorloo2, Mehdi Birjandi3
1Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
ангиотензин转化酶 (ACE I/D) 和ACE2 rs2285666的遗传变异与COVID-19的严重程度有关. 而ACE D和ACE2 G等位基因与更严重的疾病相关,而ACE I可能会提供保护.
科学领域:
- 遗传学 是一个遗传学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- COVID-19的严重程度受遗传因素的影响.
- 氨酸 - 血管素系统在COVID-19病变发生过程中发挥作用.
- 在ACE和ACE2中的遗传多态可能会影响疾病的结果.
研究的目的:
- 调查 ангиотензин转化酶插入/删除 (ACE I/D) 和 ACE2 rs2285666.6 的遗传多态性.
- 分析这些多形态与轻度,严重和严重的COVID-19症状的关联.
主要方法:
- 研究包括300名COVID-19患者在轻度,严重和关键类别.
- 通过聚合酶链反应 (PCR) 确定ACE I/D基因型.
- ACE2 rs2285666基因型通过限制片段长度多态-PCR确定.
主要成果:
- 在ACE I/D基因型和COVID-19严重程度之间发现了显著的关联 (p < 0.001).
- 与轻度病例相比,在严重/危急病例中,ACE D等位基因更为普遍 (p < 0.001).
- ACE2 rs2285666多态及其G/A基因组与疾病严重程度有显著的关联 (p <0.05),G基因组在严重/关键组中更常见.
结论:
- 同胞性ACE D/D基因型增加了对严重COVID-19的易感性.
- 而ACE I等位基因可能会对严重的COVID-19症状提供保护性优势.
- ACE2 rs2285666变种和ACE2 G/G基因型与COVID-19严重程度的增加有关.
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