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设备插入与材料:糖尿病炎症的驱动因素设备接口

Priscila Silva Cunegundes¹, Kenneth Wood¹, Jean Gabriel de Souza¹

¹Department of Physiology, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI, USA.

Journal of diabetes science and technology

|November 18, 2025

概括

尽量减少插入创伤和选择生物相容材料是改善自动化胰岛素输送 (AID) 系统的关键. 这项研究强调了材料选择和插入技术如何影响炎症反应和设备磨损时间.

科学领域:

生物材料科学生物材料科学
免疫学免疫学免疫学
医疗设备工程医疗设备工程

背景情况:

自动化胰岛素输送 (AID) 系统受到短时间的胰岛素输注组 (IIS) 磨损时间 (2-3天) 的阻碍,与更长的持续血糖监测 (CGM) 传感器寿命 (14天) 相反.
输液组的故障损害了AID的可靠性和患者的坚持.
了解IIS植入的炎症反应对于改善AID系统性能至关重要.

研究的目的:

调查插入创伤和生物材料组成在胰岛素输液套的急性炎症反应中的作用.
为了比较不同输液套材料和CGM传感器的生物相容性.
确定延长AID系统中使用的设备磨损时间的策略.

主要方法:

在猪和小鼠模型中评估了三种商业CGM传感器和两种基于Teflon的IIS导管.
在植入后一天的猪组织中评估了中性粒细胞外细胞陷 (NET) 的形成.
在植入后1天和3天的小鼠气囊模型中分析了免疫细胞透和细胞因子表达.

主要成果:

中性细胞外细胞陷 (NETs) 存在于所有插入部位,表明插入创伤是早期NET形成的主要触发因素.
龙导管诱导了长时间的炎症反应,包括巨细胞,巨细胞,TNF-α和KC/GRO水平的增加.
基于聚氨的传感器显示出最小的免疫激活,这表明与特龙相比,生物相容性更好.

结论:

减少插入创伤对于减少急性炎症反应至关重要.
选择生物相容材料,如聚氨,可以增强设备和组织的整合,并延长磨损时间.
优化材料选择和插入技术可以显著提高AID系统的可靠性和患者的结果.

关键词:

自动化胰岛素输送 (AID)生物材料是一种生物材料.持续葡萄糖监测 (CGM) 传感器异物体的反应反应胰岛素输液套件 (IIS) 是一种用于注射胰岛素的装置.

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