欧洲抗癌规范,第五版 - 激素替代疗法,其他常见的医学疗法和癌症
Mangesh A Thorat1,2, Marc Arbyn3, David Baldwin4,5
1Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, UK.
Molecular oncology
|November 18, 2025
概括
激素替代疗法 (HRT) 可能会增加癌症风险,但建议用于严重的绝经症状,当好处超过风险时. 荷尔蒙避孕药和阿司匹林没有一般人群推.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 医学疗法可以影响癌症风险.
- 激素替代疗法 (HRT) 和激素避孕药被广泛使用.
- 阿司匹林具有潜在的化学预防性质.
研究的目的:
- 为"欧洲抗癌规范" (ECAC5) 建议提供科学理由.
- 评估与HRT,荷尔蒙避孕药和阿司匹林相关的癌症风险.
- 为公共卫生战略提供有关这些广泛使用的药物的信息.
主要方法:
- 对当前科学证据的系统审查.
- 分析与HRT,荷尔蒙避孕药和阿司匹林相关的癌症风险数据.
- 在ECAC5工作组中的专家共识.
主要成果:
- 除了阴道雌激素外,所有形式的HRT都与乳腺癌风险增加有关.
- HRT也可能会增加血清性卵巢和子宫内膜癌的风险.
- 对于一般人群来说,没有对激素避孕药或阿司匹林提出任何建议.
结论:
- 在咨询医疗保健专业人员后,对于一些令人烦的更年期症状,应谨慎使用HRT,并尽可能短时间使用.
- 在特定情况下,HRT对生活质量的好处可能会超过癌症风险.
- 目前的证据不支持对荷尔蒙避孕药或阿司匹林用于预防癌症的全民推.
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