孕前持续时间对长期心血管疾病风险的影响
Nina Keitaanpää1, Jaakko S Tyrmi1,2, Elli Toivonen1,3
1Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Finland. (N.K., J.S.T., E.T., H.L.).
Hypertension (Dallas, Tex. : 1979)
|November 18, 2025
概括
妊娠前持续时间较长会增加母亲患心血管疾病的风险. 从诊断到分娩的每一天,在55岁之前,风险会增加1-2%,这表明早分娩可能是有益的.
科学领域:
- 产科和妇科 产科和妇科
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 孕前是一种与未来心血管疾病 (CVD) 风险更高相关的妊娠并发症.
- 在分娩前产前的持续时间和随后的心血管疾病风险之间的关系仍在调查中.
研究的目的:
- 调查是否预先怀孕的诊断和分娩之间的较长时间间隔与55岁之前患心血管疾病的风险增加有关.
主要方法:
- 利用来自芬兰两个队列 (FINNPEC和FinnGen) 的全国健康登记数据.
- 暴露的定义是从产前的诊断到分娩的数天时间.
- 通过使用Cox比例危险模型评估55岁之前诊断的复合心血管疾病 (高血压疾病,缺血性心脏病,动脉疾病) 结果.
主要成果:
- 妊娠前持续时间较长与两组患者的每日心血管疾病风险增加有显著的关联 (FINNPEC的HR为1.02,FinnGen的HR为1.01).
- 这些关联在调整各种混因素后仍然显著,包括母亲的BMI,年龄,婴儿大小,吸烟和糖尿病状况.
结论:
- 预计在产前的诊断和分娩之间每增加一天,在55岁之前,将心血管疾病的长期风险增加1-2%.
- 这些发现表明,被诊断患有妊娠前的妇女的早期分娩可能可能会减轻未来的心血管风险.
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