在儿科胰腺炎中糖尿病发展的早期机制:试点研究
Maria Graciela Parra Villasmil1, Melena Bellin2, Catherina Pinnaro1,3
1Department of Pediatrics, Stead Family Children's Hospital, University of Iowa, Iowa City, Iowa, USA.
Journal of pediatric gastroenterology and nutrition
|November 18, 2025
概括
患有胰腺炎的儿童经常患上糖尿病. 这项试点研究发现,35%的儿科胰腺炎患者患有失糖症,与胰岛素抵抗和荷尔蒙水平变化有关.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 内分泌学 在内分泌学.
- 代谢研究研究 代谢研究
背景情况:
- 大约9%的患有急性复发性胰腺炎 (ARP) 或慢性胰腺炎 (CP) 的儿童患有胰腺致糖尿病,终身风险接近50%.
- 关于儿科胰腺炎中糖尿病的病理生理学和风险生物标志物的数据有限.
- 这项试点研究旨在调查诊断为ARP或CP的儿童的血糖生理学.
研究的目的:
- 为了研究患有急性复发性胰腺炎 (ARP) 或慢性胰腺炎 (CP) 的儿童的血糖生理学.
- 在这个人群中确定与失糖症相关的潜在生物标志物和病理生理机制.
主要方法:
- 从INSPPIRE-2研究中注册的患有CP或ARP诊断的儿童 (5-21岁).
- 使用混合食耐受性测试 (MMTT) 来测量葡萄糖,胰岛素,C-,葡萄糖,GLP-1和PP.
- 评估的血红蛋白A1c,持续的葡萄糖监测 (CGM),HLA单元型和糖尿病自身抗体;失糖症定义为禁食葡萄糖≥100 mg/dL或HbA1c≥5.7%.
主要成果:
- 20名参与者中有7名 (35%) 患有失糖症,其中有一例以前未被识别的糖尿病.
- 患有失糖症的个体表现出胰岛素耐药性增加,较低的葡萄糖类-1 (GLP-1),以及较低胰岛素和C-水平的趋势.
- 在患有失糖症的参与者中观察到胰腺多 (PP) 水平更高的趋势.
结论:
- 在这项试点研究中,有很大一部分 (35%) 患有胰腺炎的儿童出现了失糖症.
- 儿科胰腺炎的低血糖可能与胰岛素抵抗有机械联系.
- 其他相关因素包括胰岛素分泌受损,GLP-1减少,PP水平升高.
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