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相关概念视频

Radical Reactivity: Overview01:11

Radical Reactivity: Overview

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Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
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Enzyme-linked Receptors01:00

Enzyme-linked Receptors

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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
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Toxic Reactions: Overview01:26

Toxic Reactions: Overview

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
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Reaction Mechanisms03:06

Reaction Mechanisms

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Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
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Coupled Reactions01:17

Coupled Reactions

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Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy, whereas others require energy to proceed. Cells often couple the energy-releasing reaction with the energy-requiring one to carry out important cell functions. 
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
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Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

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Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
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相关实验视频

Updated: Jan 11, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
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在Reactome知识库2026年.

Eliot Ragueneau1, Chuqiao Gong1, Pierre Sinquin1

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.

Nucleic acids research
|November 18, 2025
PubMed
概括
此摘要是机器生成的。

Reactome是一个全面的人类生物学知识库. 它更新的界面和工具增强了对生物研究的数据访问,可视化和分析.

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科学领域:

  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.
  • 系统生物学 系统生物学

背景情况:

  • Reactome提供了专家策划的关于人类分子通路的数据.
  • 它涵盖了正常的生理学和疾病机制,包括遗传和药物影响.
  • 通过对出版物的自动监控来维护数据完整性.

研究的目的:

  • 描述Reactome知识库的最新更新和功能.
  • 突出用户界面,可视化和分析工具的改进.
  • 强调Reactome对FAIR数据原则的承诺及其作为可信资源的作用.

主要方法:

  • 重新设计基于Angular的界面,改进了可访问性和模块化架构.
  • 引入了新的可视化工具:ReacFoam,增强的路径图和实体级视图 (ELV).
  • 开发了用于多omics集成和可定制可视化的新分析工具,包括聊天机器人和图标库.

主要成果:

  • 推出了一个重新设计的,用户友好的界面,具有先进的可视化功能.
  • 集成的新分析工具支持多学科数据和自然语言交互.
  • 获得了CoreTrustSeal认证,并被指定为全球核心生物数据和ELIXIR资源.

结论:

  • 更新后的Reactome知识库为分子生物学研究提供了增强的可访问性和强大的工具.
  • 新功能促进了多学科的整合,直观的导航和生物状态的比较分析.
  • Reactome对数据完整性,FAIR原则和社区参与的承诺巩固了它作为一个重要的全球资源的地位.