在Reactome知识库2026年
Eliot Ragueneau1, Chuqiao Gong1, Pierre Sinquin1
1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
Nucleic acids research
|November 18, 2025
概括
Reactome是一个全面的人类生物学知识库. 它更新的界面和工具增强了对生物研究的数据访问,可视化和分析.
科学领域:
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
- 系统生物学 系统生物学
背景情况:
- Reactome提供了专家策划的关于人类分子通路的数据.
- 它涵盖了正常的生理学和疾病机制,包括遗传和药物影响.
- 通过对出版物的自动监控来维护数据完整性.
研究的目的:
- 描述Reactome知识库的最新更新和功能.
- 突出用户界面,可视化和分析工具的改进.
- 强调Reactome对FAIR数据原则的承诺及其作为可信资源的作用.
主要方法:
- 重新设计基于Angular的界面,改进了可访问性和模块化架构.
- 引入了新的可视化工具:ReacFoam,增强的路径图和实体级视图 (ELV).
- 开发了用于多omics集成和可定制可视化的新分析工具,包括聊天机器人和图标库.
主要成果:
- 推出了一个重新设计的,用户友好的界面,具有先进的可视化功能.
- 集成的新分析工具支持多学科数据和自然语言交互.
- 获得了CoreTrustSeal认证,并被指定为全球核心生物数据和ELIXIR资源.
结论:
- 更新后的Reactome知识库为分子生物学研究提供了增强的可访问性和强大的工具.
- 新功能促进了多学科的整合,直观的导航和生物状态的比较分析.
- Reactome对数据完整性,FAIR原则和社区参与的承诺巩固了它作为一个重要的全球资源的地位.
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