对耐火性慢性鼻炎的多维预测因素的系统审查:临床,系统和局部见解
Di Wu1,2,3, Linping Shu1,2,3, Chengshuo Wang1,2,3
1Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Allergy
|November 18, 2025
概括
识别耐火性慢性鼻炎与鼻息肉 (RCRSwNP) 的预测标志物是个性化医学的关键. 这次审查发现,像E/M比率和鼻子组织中的生物标志物 (如Charcot-Leyden晶体) 等临床因素在预测RCRSwNP结果方面具有很高的准确性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生物标志物发现发现
- 精准医学是一门精准的医学.
背景情况:
- 具有鼻息肉的耐火性慢性鼻炎 (RCRSwNP) 是一个重大的临床挑战.
- 准确预测RCRSwNP对于定制有效的治疗策略至关重要.
- 现有的诊断和预测工具需要改进,以实现最佳的患者管理.
研究的目的:
- 系统地审查和评估RCRSwNP的临床特征和生物标志物的预测价值.
- 综合目前关于诊断准确性的证据,并确定关键预测因素.
- 为RCRSwNP.提供准确医学方法的发展信息.
主要方法:
- 在PubMed,EMBASE,Cochrane图书馆和科学网络中进行系统的文献搜索,直到2024年6月.
- 选6934个出版物,分析了54个符合条件的研究和450个标记.
- 标记物按样本类型 (系统或局部) 和分析方法分类;使用QUADAS-2评估偏差风险.
主要成果:
- 在临床特征中,EM比率显示出诊断准确度最高 (AUC=0.947).
- 鼻息肉组织的生物标志物,包括Charcot-Leyden晶体 (CLC) 和乙酸细胞计数,显示出高预测潜力 (AUC高达0.973).
- 非侵入性局部标记和多标记面板也表现出显著的预测准确性,超过90%的面板达到AUC>0.700.
结论:
- 临床特征和生物标志物,特别是来自鼻子组织或分泌物的局部生物标志物,是RCRSwNP的有价值的预测指标.
- 方法的标准化,更大的队列和验证研究对于提高标记器效用至关重要.
- 未来利用多主题和非侵入性采样的研究有望改善RCRSwNP的预测和治疗.
相关概念视频
01:23Chronic Pharyngitis
10.7K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
10.7K
01:16Drugs Used in Upper Respiratory Disorders: Overview
609
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
609
01:29Anatomy of Respiratory System I: Upper Respiratory Tract
4.7K
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
4.7K
01:17Drugs Used in Lower Respiratory Disorders: Overview
1.0K
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
1.0K
01:31Common Respiratory Disorders
1.3K
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
1.3K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K