基于卡利沙林的共价有机框架的孔隙细分策略,用于氨基酸的状选择性跨膜传输
Zenghui Xie1, Jiana Lin1, Yuling Hu1
1School of Chemistry, Institute of Green Chemistry and Molecular Engineering, Sun Yat-sen University, Guangzhou 510006, China.
Analytical chemistry
|November 18, 2025
概括
研究人员开发了宏循环驱动的共价有机框架 (COFs) 来精确构建纳米通道. 这些性COF能够高效和对D/L-二的分离,从而推进了膜技术.
科学领域:
- 材料科学 材料科学 材料科学
- 超分子化学 超分子化学
- 纳米技术 纳米技术
背景情况:
- 共价有机框架 (COFs) 提供可调节的纳米通道,但在精确的孔径大小和选择性识别的几何控制方面面临挑战.
- 针对定制的COF纳米通道开发方法对于先进的分离应用至关重要.
研究的目的:
- 提出一个宏观循环驱动的策略,用于构建具有精确限制空腔的COF纳米通道.
- 通过使用这些工程COF来实现高效和enantioselective的跨膜传输.
主要方法:
- 基于calixarene的COFs的制造,具有四角形和六角形的对称性,使用calix[4]arene和calix[6]arene构建块.
- 通过点击化学将β-cyclodextrin固定在COF孔壁上,以创建性环境.
- 混合矩阵膜的制备,其中包含这些合性COF.
主要成果:
- 证明了COF纳米通道孔径大小和功能的精确调节.
- 在D/L-托的跨膜运输中实现了近100%的反体过量.
- 建立了COF晶体/孔隙结构和氨基酸识别能力之间的关系.
结论:
- 宏观循环驱动的孔隙细分策略使COF人工纳米通道的精确设计成为可能.
- 开发出来的性COF膜显示出了先进的基于膜的性分离的巨大潜力.
- 这种方法有助于量身定制的构建纳米通道与受控的孔隙结构和微环境.
相关概念视频
Multi-pass Transmembrane Proteins and β-barrels
6.4K
In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
α-Helix containing multi-pass transmembrane proteins
Multi-pass transmembrane proteins such as...
α-Helix containing multi-pass transmembrane proteins
Multi-pass transmembrane proteins such as...
6.4K
Membrane Asymmetry Regulating Transporters
6.9K
Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
6.9K
Pore Transport and Ion-Pair Transport
1.1K
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
1.1K
Facilitated Diffusion
1.1K
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.1K
Clathrin Coated Vesicles
9.0K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
9.0K
Cellular Membranes and Drug Transport
1.4K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.4K


