对于囊性纤维化而言,进行非侵入性通风
André S Sousa1, César R Rocha-Filho1, Aline Rocha2
1Federal University of São Paulo, São Paulo, Brazil.
The Cochrane database of systematic reviews
|November 18, 2025
概括
对囊性纤维化 (CF) 患者的非侵入性正压通风 (NIPPV) 的证据尚不确定. 需要更多高质量的研究来确定NIPPVV.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 肺部病理学 肺部病理学
- 关键的护理关键的护理
背景情况:
- 囊性纤维化 (CF) 患者经常经历粘液滞留,呼吸困难和呼吸肌肉强度降低.
- 非侵入性正压通风 (NIPPV) 是一种治疗CF患者急性和慢性呼吸道症状的方法.
- 之前的研究已经探索了NIPPV在睡眠和运动期间空气通道清理中对CF管理的作用.
研究的目的:
- 评估NIPPV在患有囊性纤维化 (pwCF) 的人群中的效果,可接受性和个人偏好.
- 综合目前关于NIPPV在CF患者急性恶化和稳定状况的疗效的证据.
主要方法:
- 在2025年4月2日之前对临床试验注册表和参考清单进行了系统的搜索.
- 包括平行和交叉设计的随机对照试验 (RCT),将NIPPV与没有NIPPV或 pwCF 中其他治疗方法进行比较.
- 评估结果包括死亡率,生活质量,肺功能,呼吸道症状和不良事件,使用GRADE和RoB 2.0标准.
主要成果:
- 总共有14个RCT和261名参与者被纳入,大多数研究的持续时间很短 (最长3个月).
- 关于NIPPV (特别是BiPAP) 对吐,住院和患者舒适度的急性影响的证据非常不确定.
- 在稳定的CF患者中,NIPPV对肺功能 (FEV1,FVC),睡眠质量和可接受性的影响的证据也非常不确定,这是由于有限的数据和方法限制.
结论:
- 目前关于NIPPV对pwCF在肺部恶化和稳定状态期间的有效性的证据仍然不确定.
- 包含的研究存在一些局限性,包括样本规模小,对关键结果的评估不足,以及方法方面的弱点,导致显著的不确定性.
- 需要进行高质量的长期研究,以准确确定NIPPV对CF患者呼吸道清除,夜间通风和运动的益处.
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