基于氨酸的多重体A9系统的绿色合成:聚糖-A9结合物与增强的HER2受体结合亲和力以及作为活性材料的潜在生物医学应用

Valentina Verdoliva1, Alfio Pulvirenti2, Giuseppe Digilio3

  • 1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, National Research Council (CNR), Institute of Crystallography, Via Vivaldi, 43, 81100 Caserta, Italy.

Biomacromolecules
|November 18, 2025
PubMed
概括

研究人员开发了一种绿色固态方法,将A9与氨酸 (HA) 相结合. 这种新的HA-A9结合体显示了提高HER2受体亲和力和自我组装到生物医学应用中有用的结构.

相关概念视频

Recombinant DNA01:09

Recombinant DNA

Overview
Sugars as Energy Storage Molecules01:10

Sugars as Energy Storage Molecules

Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
Sugars as Energy Storage Molecules01:10

Sugars as Energy Storage Molecules

Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
Production of Pharmaceuticals01:30

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...