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Updated: Jan 11, 2026

Chemical Modification of the Tryptophan Residue in a Recombinant Ca2+-ATPase N-domain for Studying Tryptophan-ANS FRET
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Chemical Modification of the Tryptophan Residue in a Recombinant Ca2+-ATPase N-domain for Studying Tryptophan-ANS FRET

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合成策略可以在多大程度上影响循环托芬子微蛋白的结构,分子动力学和生物特性

Saranya Vasudevan1, Piotr Paluch1, Tomasz Pawlak1

  • 1Centre of Molecular and Macromolecular Studies Polish Academy of Sciences, Sienkiewicza 112, Lodz, 90-363, Poland.

Chemistry (Weinheim an der Bergstrasse, Germany)
|November 18, 2025
PubMed
概括

这项研究比较了两种循环寡,酸 (Trp_C) 和其逆序列 (Inv-cTrp_C),揭示了明显的结构和热稳定性差异. 分子动力学模拟解释了这些变化,特别是Inv-cTrp_C中的α-螺旋核和托定位.

关键词:
核磁共振光谱法 (NMR) 是一种光谱法.在 Trp-cage 中.倒置结构是一种倒置结构.迷你蛋白质微型蛋白质分子动力学分子动力学

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