基线PARP-1PET成像在患有DNA损伤反应突变的先进实体瘤的患者
Tarek Daoud1, Jiansong Chen2, Peng Wei2
1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Unit 1422, 1515 Holcombe Blvd, Houston, Houston, TX, 77030, USA.
European journal of nuclear medicine and molecular imaging
|November 18, 2025
概括
一种新的PET/CT放射追踪剂,18F-FluorThanatrace (18F-FTT),可以非侵入性地评估多聚ADP-ribose) 聚合酶 (PARP) 的活性. 标志物吸收因瘤类型,突变状态和先前治疗而异,有助于患者选择PARP抑制剂.
科学领域:
- 在瘤学瘤学.
- 核医学是一种核医学.
- 分子成像学分子成像学
背景情况:
- 聚基基聚合酶 (PARP) 抑制剂是有效的癌症治疗瘤与DNA损伤反应缺陷.
- 识别将从PARP抑制剂中受益的患者需要改进的方法.
- 对PARP活性进行非侵入性评估对于治疗选择至关重要.
研究的目的:
- 为了评估18F-FluorThanatrace (18F-FTT) PET/CT用于对PARP活性进行非侵入性评估.
- 确定18F-FTT摄入量,瘤突变状态和先前治疗之间的关联.
主要方法:
- 在接受PARP抑制剂治疗之前,对52名实体瘤患者进行了全身18F-FTTPET/CT扫描.
- 每个患者最多记录了五种病变的最大标准化吸收值 (SUVmax).
- 损伤特异性分析包括瘤类型,突变状态和先前治疗史.
主要成果:
- 在所有患者中观察到18F-FTT摄入量,根据主要瘤类型有显著差异.
- 与其他突变相比,具有BRCA2突变的病变显示出较高的18F-FTT吸收 (6.7对5.5).
- 之前的PARP抑制剂或全身治疗与较低的18F-FTTSUVmax相关.
结论:
- 18F-FTT PET/CT提供了一种非侵入性方法,用于量化固体瘤中PARP1酶活性.
- 18F-FTT的吸收受瘤突变状态和先前治疗史的影响.
- 这种标记物可能有助于选择用于PARP抑制剂治疗的患者.
更多相关视频
10:44Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
Published on: January 31, 2018
10.7K
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
11.5K
相关概念视频
01:29Positron Emission Tomography
6.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.9K
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
390
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
390