中年成人 (30-60岁) 身体活动与骨折风险之间的关联是什么:没有元分析的系统审查和综合 (SWIM)
Catherine Rolls1,2,3, Oliver Bastiani4, Manuel Antuna5
1Translational and Applied Research Group, University of Bristol, 12a Priory Road, Bristol, BS8 1TU, UK. catherine.rolls@bristol.ac.uk.
概括
中年身体活动可能会保护女性免受部骨折,但证据有限. 需要更多的研究来澄清活动强度与未来骨折风险之间的联系.
科学领域:
- 老年学是一门学科.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 研究了中年人的习惯性体力活动 (PA) 与骨折风险之间的关联.
- 解决了对中年PA如何影响后期骨折结果的清晰度的需求.
研究的目的:
- 为了确定中年人的习惯性体力活动是否与以后任何时间的骨折风险有关.
- 系统地审查有关中年身体活动和随后骨折发生率的现有文献.
主要方法:
- 对PubMed,CINAHL和Embase数据库进行系统审查.
- 包括10个队列和3个病例控制研究;使用纽卡斯尔-太华尺度评估偏差风险.
- 为了证据的确定性,采用了GRADE方法;由于异质性,采用了没有元分析的合成 (SWIM).
主要成果:
- 低确定性证据表明,中等水平的中年活动可能会保护男性免受部骨折 (2项研究).
- 中等确定性证据表明,高中期的身体活动可能会保护女性免受部骨折 (4项研究).
- 对于其他类型的骨折以及男性和女性中等/高活性 (3项研究) 存在非常低的确定性证据.
结论:
- 中年身体活动强度与随后的骨折风险之间的关系仍然不确定.
- 跨研究的PA测量和报告的高度异质性限制了最终的结论.
- 建议未来使用设备测量PA和详细的时间到事件数据进行研究,以获得更清晰的见解.
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